Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors
نویسندگان
چکیده
منابع مشابه
Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors.
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR cells.
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2016
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c5cc10301k